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Nature Medicine2026-09-21

EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse

Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04665-3 Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS relapses.

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摘要

Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04665-3 Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS relapses.

EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse

Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04665-3 Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS relapses.