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Nature Medicine, Published online: 17 September 2026; doi:10.1038/s41591-026-04646-6 Results of this study show in experimental models and data from patient cohorts that the antiseizure medication levetiracetam is associated with longer survival and reduced tumor growth in diffuse midline glioma, but not hemispheric high-grade glioma, by selectively dampening GABAergic synaptic signaling, independently of its canonical SV2A-mediated primary antiseizure mechanism.
Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma
Nature Medicine, Published online: 17 September 2026; doi:10.1038/s41591-026-04646-6 Results of this study show in experimental models and data from patient cohorts that the antiseizure medication levetiracetam is associated with longer survival and reduced tumor growth in diffuse midline glioma, but not hemispheric high-grade glioma, by selectively dampening GABAergic synaptic signaling, independently of its canonical SV2A-mediated primary antiseizure mechanism.