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Nature Mental Health2026-07-24

Reframing late life depression: from brain pathology to plasticity

Nature Mental Health, Published online: 23 July 2026; doi:10.1038/s44220-026-00692-8 Late-life depression is often viewed as a consequence of neurodegeneration or vascular brain injury, leading to therapeutic pessimism. We propose a recovery-oriented model that emphasizes brain plasticity and resilience, integrating biological, psychological and social factors to improve treatment and outcomes in older adults.

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Nature Mental Health, Published online: 23 July 2026; doi:10.1038/s44220-026-00692-8 Late-life depression is often viewed as a consequence of neurodegeneration or vascular brain injury, leading to therapeutic pessimism. We propose a recovery-oriented model that emphasizes brain plasticity and resilience, integrating biological, psychological and social factors to improve treatment and outcomes in older adults.

Reframing late life depression: from brain pathology to plasticity

Nature Mental Health, Published online: 23 July 2026; doi:10.1038/s44220-026-00692-8 Late-life depression is often viewed as a consequence of neurodegeneration or vascular brain injury, leading to therapeutic pessimism. We propose a recovery-oriented model that emphasizes brain plasticity and resilience, integrating biological, psychological and social factors to improve treatment and outcomes in older adults.